Nanomedicine as an emerging approach against intracellular pathogens.
Nanomedicine as an emerging approach against intracellular pathogens.
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纳米医学作为针对细胞内病原体的新兴方法。
DOI：
10.2147/ijn.s27285
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发表时间：
2011
影响因子：
8
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Armstead AL;Li B
结核病、肝炎和艾滋病毒/艾滋病等疾病是由细胞内病原体引起的，是全球医学界的主要负担。这些疾病的常规治疗通常包括联合药物的长期治疗，这可能会导致副作用并导致患者依从性较低。病原体存在于细胞的细胞内区室中，这为有效治疗提供了额外的障碍。因此，需要针对此类细胞内疾病的改进且更有效的疗法。这篇综述将首次总结病原体可以驻留的细胞内区室，并讨论纳米医学如何通过提供靶向、持续药物释放和药物递送到病原体细胞内位置等特性来改善细胞内疾病治疗。纳米医学的特性可能有利于开发细胞内疾病的改进或替代疗法。
Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen’s intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases.