A splitting brain: Imbalanced neural networks in schizophrenia.
A splitting brain: Imbalanced neural networks in schizophrenia.
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分裂的大脑：精神分裂症中不平衡的神经网络
DOI：
10.1016/j.pscychresns.2015.03.001
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发表时间：
2015-05-30
影响因子：
11.3
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Li M;Deng W;He Z;Wang Q;Huang C;Jiang L;Gong Q;Ziedonis DM;King JA;Ma X;Zhang N;Li T
关键大脑系统之间的连接障碍被认为是精神分裂症的病理生理学基础。本研究利用静息状态功能磁共振成像(RsfMRI)对121例首发、未接受治疗的精神分裂症患者的全脑神经网络功能障碍模式进行了研究。首先将组独立成分分析(ICA)应用于rsfMRI数据，提取了90个脑功能成分。然后评估这些ICA组件之间的功能连接，并在患者组和对照组之间进行比较。为了检查患者中显著改变的组件间连接的功能作用，每个ICA组件被归因于先前明确定义的十个大脑网络/区域中的一个。与健康对照组(n=103)相比，发现29个功能连接改变，其中19个连接增加，10个连接减少。增加的连接性主要是在默认模式网络(DMN)内以及DMN和认知网络之间，而连接性降低主要与感觉网络有关。鉴于DMN在内部心理过程和外部环境输入的感觉网络中的关键作用，这些大脑网络连接改变的模式可能表明精神分裂症患者对内部和外部信息的神经处理不平衡。
Dysconnectivity between key brain systems has been hypothesized to underlie the pathophysiology of schizophrenia. The present study examined the pattern of functional dysconnectivity across whole-brain neural networks in 121 first-episode, treatment-naïve patients with schizophrenia by using resting-state functional magnetic resonance imaging (rsfMRI). Group independent component analysis (ICA) was first applied to rsfMRI data to extract 90 functional components of the brain. The functional connectivity between these ICA components was then evaluated and compared between the patient and control groups. To examine the functional roles of significantly altered between-component connections in patients, each ICA component was ascribed to one of ten previously well-defined brain networks/areas. Relative to healthy controls (n=103), 29 altered functional connections including 19 connections with increased connectivity and 10 connections with decreased connectivity in patients were found. Increased connectivity was mainly within the default mode network (DMN) and between the DMN and cognitive networks, whereas decreased connectivity was predominantly associated with sensory networks. Given the key roles of DMN in internal mental processes and sensory networks in inputs from the external environment, these patterns of altered brain network connectivity could suggest imbalanced neural processing of internal and external information in schizophrenia.