Morphological changes of the basilar artery, ventricles, and choroid plexus after experimental SAH.
Morphological changes of the basilar artery, ventricles, and choroid plexus after experimental SAH.
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DOI：
10.3171/jns.1984.61.3.0486
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发表时间：
1984-09
影响因子：
4.1
通讯作者：
T. Liszczak;P. Black;A. Tzouras;L. Foley;N. Zervas
中科院分区：
文献类型：
--
作者：
T. Liszczak;P. Black;A. Tzouras;L. Foley;N. Zervas
采用大池三次重复注射自体非肝素化血诱导成年兔实验性蛛网膜下腔出血（SAH）。最后一次输血一周后处死动物，观察形态学变化。基底动脉未见血管病变，大部分动脉周围未见动脉周围血栓。肉眼和显微镜下可见脑室和脉络膜丛的改变。心室改变包括侧脑室扩张，纤毛室管膜细胞破坏，少量血液沉积在整个心室系统。这些心室改变与SAH患者的病理后遗症相似。脉络膜丛的改变包括电子致密的细胞质包涵体和外侧及亚细胞间隙的扩张。脑室表面和脉络膜丛都受到脑室内注射血液的影响。SAH后的脑积水可能因室管膜破裂和脑室纤毛活动丧失而加剧。脉络膜丛功能也可能发生改变。
Experimental subarachnoid hemorrhage (SAH) was induced in adult rabbits by three repeated cisterna magna injections of autologous nonheparinized blood. One week after the last blood injection the animals were sacrificed and examined for morphological change. No vasculopathy was noted in the basilar arteries and no periarterial thrombus was seen around the majority of these arteries. Gross and microscopic changes were observed in both the ventricles and choroid plexus. Ventricular changes included dilation of the lateral ventricles, destruction of ciliated ependymal cells, and deposition of small amounts of blood throughout the ventricular system. These ventricular changes are similar to the pathological sequelae of SAH in patients. Choroid plexus changes included electron-dense cytoplasmic inclusions and dilation of the lateral and subcellular spaces. The ventricular surface and the choroid plexus are both affected by the intracisternal injection of blood. The hydrocephalus that follows SAH may be potentiated by ependymal disruption and loss of ciliated activity in the ventricles. Changes in choroid plexus function may also occur.