The structural and functional diversity of metabolite-binding riboswitches.
The structural and functional diversity of metabolite-binding riboswitches.
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DOI：
10.1146/annurev.biochem.78.070507.135656
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发表时间：
2009
影响因子：
16.6
通讯作者：
Breaker RR
中科院分区：
文献类型：
--
作者：
Roth A;Breaker RR
The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. While proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.
