Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant
Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant
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DOI：
10.1080/1042819031000139774
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Lipton, JH
中科院分区：
文献类型：
--
作者：
Alabdulaaly, A;Rifkind, J;Lipton, JH
慢性费城染色体阳性CML患者，干扰素治疗后出现严重的延长线骨髓发育不全。该并发症对抗胸腺细胞球蛋白、环孢素A和强的松两疗程的免疫抑制治疗均无反应。患者继续输血依赖与费城染色体的持久性。同种异体骨髓移植恢复了正常造血功能。
A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.