LOIASIS IN ENDEMIC AND NONENDEMIC POPULATIONS - IMMUNOLOGICALLY MEDIATED DIFFERENCES IN CLINICAL PRESENTATION
LOIASIS IN ENDEMIC AND NONENDEMIC POPULATIONS - IMMUNOLOGICALLY MEDIATED DIFFERENCES IN CLINICAL PRESENTATION
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DOI：
10.1093/infdis/163.6.1318
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发表时间：
1991-06-01
影响因子：
6.4
通讯作者：
NUTMAN, TB
中科院分区：
文献类型：
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作者：
KLION, AD;MASSOUGBODJI, A;NUTMAN, TB
为了更准确地定义洛氏病的临床谱，并开始评估流行地区游客和这些地区当地人之间临床表现差异的免疫学基础，对51名西非洛氏病患者进行了评估，并与42名感染者进行了比较。外籍人士。微丝蚴血症在90%的流行病患者中存在，而Calabar saccharides仅在16%的流行病患者中存在。相反，只有10%的外籍人士是微丝蚴病，而95%的人抱怨卡拉巴尔sophila。与非流行性人群相比，流行性人群的外周血嗜酸性粒细胞，寄生虫特异性IgG和淋巴细胞增殖寄生虫抗原的水平显着降低。这些研究结果支持了这一假设，即寄生虫抗原的免疫反应的调制的差异是负责观察到的外籍和地方性人群之间的临床表现的差异与寄生虫。
To define the clinical spectrum of loiasis more precisely and to begin to assess the immunologic basis for the difference in clinical manifestations between visitors to endemic areas and natives of these areas, 51 West African patients with loiasis were evaluated and compared with 42 infected expatriates. Microfilaremia was present in 90% and Calabar swellings in only 16% of the endemic patients. Conversely, only 10% of the expatriates were microfilaremic while 95% complained of Calabar swellings. The endemic population showed significantly decreased levels of peripheral blood eosinophils, parasite-specific IgG, and lymphocyte proliferation to parasite antigens compared with the nonendemic population. These findings support the hypothesis that differences in the modulation of the immune response to parasite antigen are responsible for the observed differences in clinical presentation between expatriate and endemic populations with loiasis.