Urinary arsenic concentration adjustment factors and malnutrition
Urinary arsenic concentration adjustment factors and malnutrition
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DOI：
10.1016/j.envres.2007.08.005
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发表时间：
2008-02-01
影响因子：
8.3
通讯作者：
Vahter, Marie
中科院分区：
文献类型：
--
作者：
Nermell, Barbro;Lindberg, Anna-Lena;Vahter, Marie
这项研究旨在评估调整尿砷浓度或任何其他尿液生物标志物的适宜性，以适应营养不良人群中肌酐和比重引起的尿液稀释度的变化。我们测定了孟加拉农村地区1466名5-88岁人群的尿样中无机砷、肌酐和比重的含量。孟加拉农村是饮用水砷污染和营养不良的普遍地区(约30%的成年人体重指数低于18.5 kg/m(2))。尿肌酐浓度较低，青少年和成人平均为0.55g/L，5~12岁儿童平均为0.35g/L。因此，经肌酐校正后的尿砷浓度数值远高于相应的经比重校正后的微克/L数据。通过多元回归分析，经比重调整后的尿肌酐受身体大小、年龄、性别和季节的影响比比重更大。此外，还发现尿肌酐与尿砷显著相关，这进一步取消了肌酐调节的资格。(C)2007 Elsevier Inc.保留所有权利。
This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population. We measured the concentrations of metabolites of inorganic arsenic, creatinine and specific gravity in spot urine samples collected from 1466 individuals, 5-88 years of age, in Matlab, rural Bangladesh, where arsenic-contaminated drinking water and malnutrition are prevalent (about 30% of the adults had body mass index (BMI) below 18.5 kg/m(2)). The urinary concentrations of creatinine were low; on average 0.55 g/L in the adolescents and adults and about 0.35 g/L in the 5-12 years old children. Therefore, adjustment by creatinine gave much higher numerical values for the urinary arsenic concentrations than did the corresponding data expressed as mu g/L, adjusted by specific gravity. As evaluated by multiple regression analyses, urinary creatinine, adjusted by specific gravity, was more affected by body size, age, gender and season than was specific gravity. Furthermore, urinary creatinine was found to be significantly associated with urinary arsenic, which further disqualifies the creatinine adjustment. (c) 2007 Elsevier Inc. All rights reserved.