Hypothyroidism and its Association with Systemic Lupus Erythematosus: A Cross Sectional Study in Chinese Patients
Hypothyroidism and its Association with Systemic Lupus Erythematosus: A Cross Sectional Study in Chinese Patients
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DOI：
10.1016/j.amjms.2020.08.026
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发表时间：
2021-01-01
影响因子：
3.1
通讯作者：
Zhang, Weiru
中科院分区：
文献类型：
--
作者：
Li, Jiarong;Wang, Xuan;Zhang, Weiru
背景：系统性红斑狼疮（SLE）患者甲状腺功能减退的相关因素尚不清楚。因此，我们的目的是评估甲状腺功能障碍的患病率在中国SLE患者和临床甲状腺功能减退症和SLE.Methods之间的关系：我们进行了一项横断面研究，甲状腺功能障碍的患病率在672例SLE患者和605名年龄和性别匹配的健康对照。比较了58例SLE合并甲状腺功能减退症患者和197例SLE合并甲状腺功能正常患者的人口统计学、临床和生化数据。采用二项逻辑回归分析进行多变量分析。斯皮尔曼等级相关被用来确定甲状腺功能和疾病activity.Results之间的关联：甲状腺功能障碍的患病率显着高于SLE患者比对照组（70.7%比19.7%）。SLE与甲状腺功能减退症的发生率较高（9.6%，P
Background: Specific factors correlated with hypothyroidism in systemic lupus erythematosus (SLE) patients remain unclear. Therefore, we aim to evaluate the prevalence of thyroid dysfunction in Chinese patients with SLE and the relationship between clinical hypothyroidism and SLE.Methods: We conducted a cross sectional study of the prevalence of thyroid dysfunction in 672 patients with SLE and 605 age- and sex-matched healthy controls. Demographic, clinical, and biochemical data were compared between 58 patients with SLE with hypothyroidism and 197 patients with SLE with euthyroidism. Multivariate analysis was performed using binomial logistic regression analysis. Spearman's rank correlation was used to identify an association between thyroid function and disease activity.Results: The prevalence of thyroid dysfunction was significantly higher in patients with SLE than in controls (70.7% vs 19.7%). SLE was associated with higher rates of hypothyroidism (9.6%, P