Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats.
Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats.
复制标题
尼卡地平可减少大鼠局部脑缺血中的钙积累和电解质紊乱。
DOI：
10.1161/01.str.19.9.1125
复制
发表时间：
1988
期刊：
影响因子：
8.3
通讯作者：
Flamm,ES
中科院分区：
文献类型：
--
作者：
Hadani,M;Young,W;Flamm,ES
我们研究了钙通道阻滞剂尼卡地平对大脑中动脉永久性闭塞后7只Sprague-Dawley大鼠脑中局部组织Ca 2+、Na+、K+和水转移的影响。我们还评估了[14 C]尼卡地平进入5只大鼠的大脑;[14 C]尼卡地平的最高浓度位于梗死区。与六只未治疗的大鼠相比，动脉闭塞后6小时，尼卡地平治疗显着减少了大脑中动脉区域的Ca 2+积聚60%。从动脉闭塞后5分钟开始，每30分钟给予8次125 μ g/kg的尼卡地平推注，动脉闭塞后6小时，大脑中动脉区域的Na+和K+位移分别显著降低40%和50%。尼卡地平减少Ca 2+积累的作用似乎大于其减少Na+和水分积累以及K+损失的作用。我们的研究结果表明，钙通道阻滞剂可以保护局灶性脑梗死模型中的脑组织，直接减少Ca 2+进入缺血细胞。
We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentrations of [14C]nicardipine were in the infarcted area. Nicardipine treatment significantly reduced Ca2+ accumulation in the middle cerebral artery territory by 60% compared with six untreated rats 6 hours after arterial occlusion. Eight 125-micrograms/kg boluses of nicardipine given every 30 minutes starting 5 minutes after arterial occlusion also significantly reduced the Na+ and K+ shifts in the middle cerebral artery territory by 40% and 50%, respectively, 6 hours after arterial occlusion. Nicardipine appears to reduce Ca2+ accumulation more than it reduces Na+ and water accumulation and K+ loss. Our results suggest that a calcium channel blocker can protect brain tissues in a model of focal cerebral infarction by directly reducing Ca2+ entry into ischemic cells.