Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain
Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain
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DOI：
10.1093/gerona/55.9.b448
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发表时间：
2000-09-01
影响因子：
5.1
通讯作者：
Dunlop, C
中科院分区：
文献类型：
--
作者：
Magnusson, KR;Scanga, C;Dunlop, C
这项研究调查了狗的衰老过程是否与吸入麻醉的敏感性增加有关，以及谷氨酸受体的年龄相关变化是否与敏感性增加有关。2-3岁奥尔兹的异氟烷平均最小肺泡浓度（MAC）为1.82 +/- .08%，11只西尔斯犬为1.45 +/- .06%，表明与幼龄犬相比，老年犬中异氟烷的效力增加。这些老年动物还显示，[H-3]谷氨酸和[H-3]地佐环平（[H-3] MK 801）与多个皮质和海马区域中N-甲基-D-天冬氨酸（NMDA）受体的结合显著降低。使用单一浓度的配体，与皮质中NMDA受体的结合密度与个体MAC值显著相关。这些结果表明，犬的麻醉效力随着年龄的增长而增加，与人类相似，NMDA受体的年龄相关变化可能代表了麻醉敏感性增加的一种机制。
This study investigated whether the aging process in dogs is associated with an increased sensitivity to inhalation anesthesia and whether age-related changes in glutamate receptors are related to the increased sensitivity. The mean minimum alveolar concentration (MAC) of isoflurane was 1.82 +/- .08% for 2-3 year olds and 1.45 +/- .06% for 11 Sears olds, indicating that there was an increased potency of isoflurane in the older dogs as compared to the young. These older animals also showed a significant decrease in binding of [H-3]glutamate and [H-3]dizocilpine ([H-3]MK801) to N-methyl-D-aspartate (NMDA) receptors in multiple cortical and hippocampal regions. The density of binding to NMDA receptors in the cortex, using a single concentration of ligand, correlated significantly with individual MAC values. These results demonstrate that dogs experience an increase in anesthetic potency with increased age, similar to humans, and that age-related changes in the NMDA receptor may represent one mechanism underlying this increased sensitivity to anesthesia.