Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings
Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings
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DOI：
10.1007/s00234-015-1603-8
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发表时间：
2016-02-01
期刊：
影响因子：
2.8
通讯作者：
Terayama, Yasuo
中科院分区：
文献类型：
--
作者：
Ito, Kenji;Kudo, Masako;Terayama, Yasuo
中脑导水管周围灰质(PAG)被认为在偏头痛的发生中起着重要作用，但影像研究的结果仍不清楚。因此，我们研究了弥散峰度成像(DKI)能否检测到偏头痛患者PAG的变化。我们使用3T磁共振成像仪获得了20名发作期偏头痛患者和20名健康对照的DKI原始图像。生成平均峰度(MK)、分数各向异性(FA)和平均弥散率(MD)图，并使用基于图谱的感兴趣区分析自动测量PAG和其他深部灰质和白质结构的值。偏头痛患者PAG的MK和MD值明显高于对照组(p<；0.05)。FA值差异无统计学意义。在患者和对照组之间，其他结构的测量指标没有显著差异。单因素分析显示，偏头痛患者组PAG的MK值与年龄和未治疗时间均呈显著正相关(r分别为0.53和0.56；p<；0.05)，但多因素分析未见相关。DKI检测到偏头痛患者PAG的MK值和MD值显著增加，提示PAG的结构变化与偏头痛的病理生理机制有关。
The periaqueductal gray matter (PAG) is considered to play an important role in generating migraine, but findings from imaging studies remain unclear. Therefore, we investigated whether diffusion kurtosis imaging (DKI) can detect changes in the PAG of migraine patients.We obtained source images for DKI from 20 patients with episodic migraine and 20 healthy controls using a 3 T magnetic resonance imaging scanner. Mean kurtosis (MK), fractional anisotropy (FA), and mean diffusivity (MD) maps were generated, and the values of the PAG and other deep gray and white matter structures were automatically measured using an atlas-based region-of-interest analysis. The metrics of these structures were compared between the patients and controls.The MK and MD values of the PAG were significantly increased in the migraine patients compared with the controls (p < 0.05). The FA values were not significantly different. There were no significant differences in the metrics of the other structures between the patients and controls. The MK values of the PAG were significantly positively correlated with both age and the untreated period in the patient group under univariate analysis (r = 0.53 and 0.56, respectively; p < 0.05) but not multivariate analysis.DKI detected significant increases in the MK and MD values of the PAG in patients with migraine, which suggests that structural changes in the PAG are associated with the pathophysiological mechanisms of migraine.