Concordant Patterns of Brain Structure in Mothers with Recurrent Depression and Their Never-Depressed Daughters.
Concordant Patterns of Brain Structure in Mothers with Recurrent Depression and Their Never-Depressed Daughters.
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DOI：
10.1159/000444448
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发表时间：
2016
影响因子：
2.9
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Foland-Ross LC;Behzadian N;LeMoult J;Gotlib IH
越来越多的研究表明，母亲有重度抑郁症（MDD）病史是青少年后代患抑郁症的最强预测因素之一。然而，很少有研究评估这种抑郁症风险增加的神经标志物，或检查是否与抑郁症母亲的神经异常有关的风险相关异常。我们通过研究两组参与者大脑结构的一致性来解决这些问题：有抑郁症病史的母亲和他们从未抑郁过的女儿，以及从未抑郁过的母亲和他们从未抑郁过的女儿。我们对有抑郁症复发史的母亲（缓解组; RMD）和无抑郁症复发史的母亲（对照组; CTL）及其从未抑郁的女儿进行了扫描，计算了皮质灰质厚度，并测试了母亲的厚度是否预测了女儿的厚度。RMD母亲和他们的高风险的女儿表现出较薄的皮质灰质与他们的CTL /低风险的同行相比，局灶性区域。重要的是，RMD母亲的厚度异常的程度预测类似的异常，在他们的女儿，这种模式是不存在的CTL /低风险的二联体。我们确定了可能导致MDD风险代际传递的神经解剖学风险因素。我们的研究结果表明，有一致性的大脑结构中的二分体，是受母亲抑郁症，和神经异常的位置，方向和程度在高风险的后代反映了他们的复发性抑郁症的母亲。
A growing body of research has demonstrated that having a mother with a history of Major Depressive Disorder (MDD) is one of the strongest predictors of depression in adolescent offspring. Few studies, however, have assessed neural markers of this increased risk for depression, or examined whether risk-related anomalies in adolescents at maternal risk for depression are related to neural abnormalities in their depressed mothers. We addressed these questions by examining concordance in brain structure in two groups of participants: mothers with a history of depression and their never-depressed daughters, and never-depressed mothers and their never-depressed daughters. We scanned mothers with (remitted; RMD) and without (control; CTL) a history of recurrent episodes of depression and their never-depressed daughters, computed cortical gray matter thickness, and tested whether mothers’ thickness predicted daughters’ thickness. Both RMD mothers and their high-risk daughters exhibited focal areas of thinner cortical gray matter compared with their CTL / low-risk counterparts. Importantly, the extent of thickness anomalies in RMD mothers predicted analogous abnormalities in their daughters; this pattern was not present in CTL / low-risk dyads. We identified neuroanatomical risk factors that may underlie the intergenerational transmission of risk for MDD. Our findings suggest that there is concordance in brain structure in dyads that is affected by maternal depression, and that the location, direction, and extent of neural anomalies in high-risk offspring mirror those of their recurrent depressed mothers.