Dietary intake of folate and risk of stroke in US men and women - NHANES I Epidemiologic Follow-up Study
Dietary intake of folate and risk of stroke in US men and women - NHANES I Epidemiologic Follow-up Study
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DOI：
10.1161/01.str.0000014607.90464.88
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发表时间：
2002-05-01
期刊：
影响因子：
8.3
通讯作者：
Whelton, PK
中科院分区：
文献类型：
--
作者：
Bazzano, LA;He, J;Whelton, PK
背景和目的：很少有基于人群的研究探讨叶酸的饮食摄入与中风和心血管疾病（CVD）风险之间的关系。本研究探讨叶酸的饮食摄入量和随后的中风和CVD的风险之间的关联。方法研究参与者包括9764名美国男性和女性年龄在25至74岁谁参加了全国健康和营养检查调查I流行病学随访研究（NHEFS），并在基线无心血管疾病。使用24小时膳食回忆评估基线时叶酸的膳食摄入量，并使用ESHA软件计算。中风和心血管疾病的发病率数据，从医疗记录和死亡certifications.Results-Over平均19年的后续行动，926事件中风事件和3758事件心血管疾病事件记录。卒中事件的相对危险度（RR）为0.79（95%置信区间[CI]：0.63 - 0.99，P=0.03），
Background and Purpose-Few population-based studies have examined the relationship between dietary intake of folate and risk of stroke and cardiovascular disease (CVD). This study examines the association between dietary intake of folate and the subsequent risk of stroke and CVD.Methods-Study participants included 9764 US men and women aged 25 to 74 years who participated in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (NHEFS) and were free of CVD at baseline. Dietary intake of folate was assessed at baseline using a 24-hour dietary recall and calculated using ESHA software. Incidence data for stroke and CVD were obtained from medical records and death certificates.Results-Over an average of 19 years of follow-up, 926 incident stroke events and 3758 incident CVD events were documented. The relative risk (RR) was 0.79 (95% confidence interval [CI], 0.63 to 0.99, P=0.03 for trend) for incident stroke events and 0.86 (95% CI: 0.78 to 0.95, P