Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.
Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.
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DOI：
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发表时间：
2015-09
影响因子：
3.7
通讯作者：
W. Alwan;F. Nestle
中科院分区：
文献类型：
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作者：
W. Alwan;F. Nestle
牛皮癣是一种常见的慢性炎症性皮肤病，与多系统表现有关，包括关节炎和肥胖。我们对疾病病因的了解，包括关键的基因组、免疫和环境因素，已经导致了有针对性的、精确的治疗方法的发展，减轻了患者的发病率。本文综述了银屑病的主要病理生理途径和治疗靶点，并强调了未来银屑病研究的兴趣领域。
Psoriasis is a common, chronic inflammatory skin disease associated with multi-system manifestations including arthritis and obesity. Our knowledge of the aetiology of the condition, including the key genomic, immune and environmental factors, has led to the development of targeted, precision therapies that alleviate patient morbidity. This article reviews the key pathophysiological pathways and therapeutic targets and highlights future areas of interest in psoriasis research.