Gallbladder mucosal function: studies in absorption and secretion in humans and in dog gallbladder epithelium.
Gallbladder mucosal function: studies in absorption and secretion in humans and in dog gallbladder epithelium.
复制标题
胆囊粘膜功能：人类和狗胆囊上皮吸收和分泌的研究。
DOI：
10.1152/ajpgi.1992.263.1.g69
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Lee,SP
中科院分区：
文献类型：
--
作者：
Igimi,H;Yamamoto,F;Lee,SP
胆囊通常被认为是一个吸收器官，使得稀释的肝胆汁被储存和浓缩。我们研究了35例急性胆囊炎经皮经鞘胆囊引流后恢复的患者。禁食一夜后，胆囊胆汁呈深棕色，脂质成分广泛分散。餐后2小时，胆囊胆汁呈乳白色白色，具有细胞外液的成分。在所有35例患者中均观察到这种现象，并且在重复研究5例患者时也始终可重现。我们使用正常的狗胆囊上皮细胞单层培养，并检查钠通量。对照组胆囊细胞吸收钠。当加入胰泌素（0.5-2.5 × 10（-7）M）时，钠流迅速逆转，导致净分泌。我们的结论是分泌是胆囊粘膜的生理功能。进食后，神经和体液因素将储存的和新分泌的胆汁转移到十二指肠，并诱导主动从头分泌，从而产生乳白色白色且不含脂质的胆囊胆汁。我们的研究结果也有重要的意义上的起源的病理性“白色胆汁”，胆囊泥的发病机制和治疗，以及动力学分析的化合物进行肠肝再循环。
The gallbladder is conventionally regarded as an absorptive organ such that dilute hepatic bile is both stored and concentrated. We studied 35 patients who had recovered from a percutaneous transhepatic gallbladder drainage performed for acute cholecystitis. After an overnight fast, gallbladder bile was dark brown in color and had a wide scatter in the lipid composition. Two hours after a meal, the gallbladder bile was opalescent white in color and had the composition of an extracellular fluid. This phenomenon was uniformly observed in all 35 patients and was also consistently reproducible when five patients were repeatedly studied. We used normal dog gallbladder epithelial cell monolayers grown in culture and examined sodium flux. Control gallbladder cells absorbed sodium. When secretin (0.5-2.5 x 10(-7) M) was added, there was a prompt reversal of sodium flux, resulting in net secretion. We conclude that secretion is a physiological function of the gallbladder mucosa. After feeding, the neural and humoral factors divert stored and newly secreted bile into the duodenum and induce active de novo secretion thus producing a gallbladder bile that is opalescent white with no lipids. Our results also have important implications on the origin of the pathological "white bile," the pathogenesis and treatment of gallbladder sludge, as well as the kinetic analysis of compounds undergoing enterohepatic recirculation.