Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
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在类似神经病理性疼痛的状态下，脊髓μ-阿片受体脱敏时间的延长可能参与了μ-阿片类药物抗过敏耐受性的形成。
DOI：
10.1111/j.1369-1600.2011.00354.x
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发表时间：
2013-07
影响因子：
3.4
通讯作者：
Suzuki T
中科院分区：
文献类型：
--
作者：
Narita M;Imai S;Nakamura A;Ozeki A;Asato M;Rahmadi M;Sudo Y;Hojo M;Uezono Y;Devi LA;Kuzumaki N;Suzuki T
在本研究中，我们研究了在神经病理性疼痛样状态下对μ-阿片受体（莫尔）激动剂的抗痛觉过敏作用的耐受性的可能发展。重复治疗芬太尼，而不是吗啡或羟考酮，产生了快速发展的耐受性，其抗痛觉过敏作用的小鼠坐骨神经结扎。与行为研究一样，在体内重复注射芬太尼的神经结扎小鼠的脊髓中获得的膜中，芬太尼诱导的G蛋白活化显著减少。在β-内啡肽基因敲除小鼠神经结扎后，对芬太尼抗痛觉过敏作用的耐受性被消除，芬太尼神经结扎后减少的G蛋白激活被逆转至正常水平。目前的研究结果表明，在神经性疼痛样状态下，脊髓内释放的β-内啡肽可能与芬太尼耐受性的快速发展有关。
In the present study, we investigated the possible development of tolerance to the antihyperalgesic effect of μ-opioid receptor (MOR) agonists under a neuropathic pain-like state. Repeated treatment with fentanyl, but not morphine or oxycodone, produced a rapid development of tolerance to its antihyperalgesic effect in mice with sciatic nerve ligation. Like the behavioral study, G-protein activation induced by fentanyl was significantly reduced in membranes obtained from the spinal cord of nerve-ligated mice with in vivo repeated injection of fentanyl. In β-endorphin-knockout mice with nerve ligation, developed tolerance to the antihyperalgesic effect of fentanyl was abolished, and reduced G-protein activation by fentanyl after nerve ligation with fentanyl was reversed to the normal level. The present findings indicate that released β-endorphin within the spinal cord may be implicated in the rapid development of tolerance to fentanyl under a neuropathic pain-like state.
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影响因子：
3.3
作者：
Walwyn, WM;Keith, DE;Maidment, NT
通讯作者：
Maidment, NT
影响因子：
5.3
作者：
Debic, HH;Kim, KA;von Zastrow, M
通讯作者：
von Zastrow, M
影响因子：
7.4
作者：
SELTZER, Z;DUBNER, R;SHIR, Y
通讯作者：
SHIR, Y
影响因子：
64.8
作者：
Bohn, LM;Gainetdinov, RR;Caron, MG
通讯作者：
Caron, MG
DOI：
10.1073/pnas.93.9.3995
发表时间：
1996-04-30
影响因子：
11.1
作者：
Rubinstein, M;Mogil, JS;Low, MJ
通讯作者：
Low, MJ