Thyrotropin-releasing hormone is not the sole physiologic mediator of prolactin release during suckling.
Thyrotropin-releasing hormone is not the sole physiologic mediator of prolactin release during suckling.
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促甲状腺激素释放激素并不是哺乳期间催乳素释放的唯一生理介质。
DOI：
10.1056/nejm197405232902103
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
James E. Zuckerman
中科院分区：
文献类型：
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作者：
Kaare M. Gautvik;A. H. Tashjian;I. Kourides;B. Weintraub;C. Graeber;Farahe Maloof;K. Suzuki;James E. Zuckerman
摘要哺乳使7例产后妇女血清催乳素升高，但对循环促甲状腺激素、三碘甲腺原氨酸和甲状腺激素无影响。注射6和300μg促甲状腺激素释放激素可提高血清催乳素和促甲状腺激素的浓度，但不能提高三碘甲腺原氨酸和甲状腺激素的浓度。1或2μg的促甲状腺激素释放激素对催乳素或促甲状腺激素均无影响，但在3名受试者中，6μg引起的血清催乳素和促甲状腺激素的相对增加相似。产后脑下垂体中的哺乳细胞和促甲状腺细胞似乎对外源促甲状腺激素释放激素的反应相似，未能观察到哺乳时促甲状腺激素的释放并不是由于高水平的循环甲状腺激素阻断了促甲状腺激素的反应。因此，哺乳引起的血清催乳素的选择性升高并不完全是由内源性促甲状腺激素释放激素引起的。(英国医学杂志290：1162-1165,1974)
Abstract Suckling elevated serum prolactin but had no effect on circulating thyrotropin, tri-iodothyronine and thyroxine in seven post-partum women. Injections of 6 and 300 μg of thyrotropin-releasing hormone raised serum concentrations of both prolactin and thyrotropin, but not of tri-iodothyronine and thyroxine. One or 2 μg of thyrotropin-releasing hormone had no effect on either prolactin or thyrotropin, although in three subjects, 6 μg caused similar relative increases in both serum prolactin and thyrotropin. Lactotrophs and thyrotrophs in the post-partum pituitary gland appear to be similarly responsive to exogenous thyrotropin-releasing hormone, and the failure to observe thyrotropin release with suckling is not due to blockade of the response of thyrotrophs by high levels of circulating thyroid hormones. The selective increase in serum prolactin induced by suckling, therefore, is not caused solely by release of endogenous thyrotropin-releasing hormone. (N Engl J Med 290:1162–1165, 1974)