Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients
Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients
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DOI：
10.1016/j.fertnstert.2008.04.068
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发表时间：
2009-07-01
影响因子：
6.7
通讯作者：
Lin, Qide
中科院分区：
文献类型：
--
作者：
Yang, Hui;Qiu, Lihua;Lin, Qide
Objective: To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood after lymphocyte therapy in unexplained recurrent spontaneous abortion (URSA) patients.Design: Prospective cohort study.Setting: University Hospital.Patient(s): Twenty-five URSA patients.Intervention(s): Measurements of CD4(+)CD25(+) regulatory T cells in peripheral blood before and after paternal or third-party lymphocyte immunization.Main Outcome Measure(S): The proportion of CD4(+)CD25(bright) regulatory T cells and the percentage of CD25(bright) cells in the CD4(+) T-cell population.Result(s): The proportion of CD4(+)CD2(bright) T cells in peripheral blood from URSA patients was increased significantly after paternal or third-party lymphocyte immunization therapy, whereas the percentage of CD4(+)CD25(dim) cells were decreased significantly. The percentage of CD4(+)CD25(bright) , cells in the CD4(+) T-cell population was significantly increased, and the proportion of CD4(+)CD25(bright) cells was significantly higher in successfully pregnant women than in those with pregnancy loss after lymphocyte therapy.Conclusion(s): Allogeneic lymphocyte therapy can enhance the percentage of CD4(+)CD25(bright) regulatory T cells in peripheral blood, therefore CD4(+)CD25(+) regulatory T cells may serve as a novel biomarker for monitoring allogeneic lymphocyte therapy in URSA patients. (Fertil Steril (R) 2009;92:301-5. (C) 2009 by American Society for Reproductive Medicine.)
