Lewis Score Correlates More Closely with Fecal Calprotectin Than Capsule Endoscopy Crohn's Disease Activity Index
Lewis Score Correlates More Closely with Fecal Calprotectin Than Capsule Endoscopy Crohn's Disease Activity Index
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DOI：
10.1007/s10620-011-1956-8
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Plevris, John N.
中科院分区：
文献类型：
--
作者：
Koulaouzidis, Anastasios;Douglas, Sarah;Plevris, John N.
小肠胶囊式内窥镜（SBCE）是一种非常宝贵的小肠成像方法。已经开发了刘易斯评分（LS）和胶囊内镜克罗恩病活动指数（CECDAI），以标准化小肠炎症的报告。粪便钙卫蛋白（FC）是一种高度可靠的肠道炎症生物标志物，通过将其与两种SBCE炎症评分系统的相关性来评估它们的性能。此外，为了定义CECDAI的阈值水平，回顾性研究;接受SBCE并在SBCE之前或之后不久进行FC测量的患者。LS和CECDAI由一名审查员计算，并将[斯皮尔曼（r（s））]与FC结果相关联。采用线性回归分析确定CECDAI的阈值水平。49例患者分为A、B和C三个亚组（分别基于FC水平< 100、100-200和千分之一200 μ g/g）。LS似乎与FC相关（r（s）= 0.448，p = 0.0014），与CECDAI不同，CECDAI未显示显著相关性（r（s）= 0.245，p = 0.089）。在A亚组中观察到FC与LS之间的强正相关（r（s）= 0.68，p = 0.0047），而在B和C亚组中，LS和CECDAI均未显示与FC相关。LS和CECDAI之间存在显著相关性（r（s）= 0. 05）。6324，p < 0.0001）。线性回归分析表明，LS阈值135和790分别对应于CECDAI水平3.8和5.8，LS在描述小肠炎症方面优于CECDAI，特别是在FC水平< 100 μ g/g时。此外，3.8和5.8的CECDAI水平似乎分别对应于135和790的LS阈值。
Small-bowel capsule endoscopy (SBCE) is an invaluable imaging method for the small bowel. The Lewis score (LS) and the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) have been developed to standardize the reporting of small-bowel inflammation. Fecal calprotectin (FC) represents a highly reliable biomarker of intestinal inflammation.To assess the performance of the two SBCE inflammation scoring systems by correlating them with FC. Furthermore, to define threshold levels for CECDAI.Retrospective study; patients who underwent SBCE and had FC measurement shortly before or after SBCE. LS and CECDAI were calculated by a single reviewer and correlated [Spearman's (r (s) )] with the FC results. Linear regression analysis was used to identify threshold levels for CECDAI.Forty-nine patients; three subgroups A, B and C (based on FC levels < 100, 100-200, and a parts per thousand yen200 mu g/g, respectively). LS appears to correlate with FC (r (s) = 0.448, p = 0.0014), unlike CECDAI, which does not demonstrate significant correlation (r (s) = 0.245, p = 0.089). Strongly positive correlation between FC and LS was observed in subgroup A (r (s) = 0.68, p = 0.0047), while in subgroups B and C, neither LS nor CECDAI showed correlation with FC. Significant correlation between LS and CECDAI was demonstrated (r (s) = 0. 6324, p < 0.0001). Linear regression analysis demonstrates that LS thresholds of 135 and 790 correspond with CECDAI levels of 3.8 and 5.8, respectively.LS performs better than CECDAI in describing small-bowel inflammation, especially at FC levels of < 100 mu g/g. Furthermore, CECDAI levels of 3.8 and 5.8 seem to correspond to LS thresholds of 135 and 790, respectively.