Neurotransmitter glutamate: its clinical importance
Neurotransmitter glutamate: its clinical importance
复制标题
神经递质谷氨酸：其临床重要性
DOI：
--
复制
发表时间：
1986
影响因子：
3.5
通讯作者：
B. Engelsen
中科院分区：
文献类型：
--
作者：
B. Engelsen
摘要兴奋性氨基酸谷氨酸在哺乳动物中枢神经系统（CNS）中具有多种重要功能。本文综述了谷氨酸的递质作用，并讨论了临床神经相关的解剖学和药理学数据。与改变的含量、摄取相关的实验和临床条件。膜结合或释放谷氨酸在中枢神经系统进行了讨论。此类病症包括癫痫、基底神经节病症、脑缺血、缺氧、低血糖、代谢性脑病、橄榄体脑桥小脑萎缩和小脑共济失调、氨基酸病、精神和其它神经病症。除了少数纤维系统外，很难区分谷氨酸和天冬氨酸作为中枢神经系统递质。因此，除非特别说明，术语谷氨酸盐以谷氨酸盐和/或天冬氨酸盐的含义使用。
Abstract Excitatory amino acid glutamate has several important functions in the mammalian central nervous system (CNS). This review focuses on the transmitter role of glutamate and discusses anatomical and pharmacological data of clinical neurological relevance. Experimental and clinical conditions which have been associated with altered content, uptake. membrane binding or release of glutamate in the CNS are discussed. Such conditions include, epilepsy, disorders of the basal ganglia, cerebral ischemia, hypoxia, hypoglycemia, metabolic encephalopathies, olivopontocerebellar atrophy and cerebellar ataxias, amino acidopathies, mental and other neurological disorders. With the exception of a few fibre systems, it is very difficult to differentiate between glutamate and aspartate as CNS transmitters. The term glutamate is, thus, used in the sense glutamate and/or aspartate unless specifically stated.
神经化学物质与选择性神经元脆弱性相关。
影响因子：
--
作者：
Wieloch,T
通讯作者：
Wieloch,T
橄榄脑桥小脑萎缩中神经兴奋性氨基酸代谢异常。
影响因子：
--
作者：
Plaitakis,A
通讯作者：
Plaitakis,A