Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion
Recovery of Skin Barrier After Stratum Corneum Removal by Microdermabrasion
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DOI：
10.1208/s12249-011-9715-x
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发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Prausnitz, Mark
中科院分区：
文献类型：
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作者：
Andrews, Samantha;Lee, Jeong Woo;Prausnitz, Mark
微晶磨皮术被广泛用作非侵入性美容技术，其最近已适于选择性地去除角质层以增加用于经皮药物递送的皮肤渗透性。本研究测量了无毛豚鼠使用微晶磨皮术去除角质层后皮肤屏障恢复的动力学。在每只动物的两个部位磨损皮肤，其中一个在闭塞下恢复，而另一个保持未闭塞。组织学测量结果表明，皮肤屏障性能磺酰罗丹明B在12小时内基本恢复，角质层出现在24小时内很大程度上改造闭塞和非闭塞的皮肤。皮肤电阻测量显示皮肤屏障在24小时内显著恢复。我们的结论是，经皮给药可能会发生长达12小时后，在豚鼠微晶磨皮，然而，人类可能会有一个更长的恢复时间，由于预期较慢的皮肤愈合率。
Microdermabrasion is widely used as a non-invasive cosmetic technique that has recently been adapted to selectively remove stratum corneum to increase skin permeability for transdermal drug delivery. This study measured the kinetics of skin barrier recovery after stratum corneum removal using microdermabrasion in hairless guinea pigs. The skin was abraded at two sites on each animal, one of which was allowed to recover under occlusion while the other remained non-occluded. Histological measurements showed that skin barrier properties to sulforhodamine B largely recovered within 12 h, and the stratum corneum appeared largely reformed within 24 h for both occluded and non-occluded skin. Skin electrical resistance measurements showed significant recovery of the skin barrier within 24 h. We conclude that transdermal drug delivery may occur for up to 12 h after microdermabrasion in guinea pigs; however, humans will probably have a longer recovery time due to expected slower skin healing rates.