Effects of oral adsorbent AST-120 (Kremezin®) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats
Effects of oral adsorbent AST-120 (Kremezin®) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats
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作者：
Kobayashi, N;Maeda, A;Ise, M
本研究的目的是确定口服吸附剂（AST-120, Kremezin(R)）治疗是否可以减少尿白蛋白排泄和血清硫酸吲哚酚（s-IS），并预防早期肾衰竭的肾小球硬化，即在次总计（3/4）肾切除术大鼠中，血清肌酐（s-Cr）为0.9-1.2 mg/dl，血尿素氮（BUN）为60-95 mg/dl。ast -120处理大鼠s-Cr和s-IS水平明显低于未处理的对照组大鼠。ast -120处理大鼠肌酐清除率升高。ast -120处理大鼠尿蛋白和硫酸吲哚酚排泄量也显著低于未处理的对照组大鼠。ast -120治疗组大鼠肾小球簇面积与鲍曼囊面积之比（GT/BC）显著低于未治疗组。ast -120治疗组大鼠肾小球硬化和小管间质纤维化程度明显低于未治疗组。此外，GT/BC程度、肾小球硬化、小管间质纤维化与尿蛋白排泄水平有显著相关性。提示AST-120可能降低s-Cr和s-IS的积累，预防肾大部切除大鼠早期肾功能衰竭的肾小球硬化。版权所有(C) 2002 S. Karger AG，巴塞尔。
The aim of the present study was to determine if treatment with an oral adsorbent (AST-120, Kremezin(R)) might decrease the urinary albumin excretion and serum indoxyl sulfate (s-IS), and prevent glomerular sclerosis in early-stage renal failure, i.e. 0.9-1.2 mg/dl of serum creatinine (s-Cr) and 60-95 mg/dl of blood urea nitrogen (BUN), in subtotal (3/4) nephrectomized rats. Levels of s-Cr and s-IS in the AST-120-treated rats were significantly lower than those in the untreated control rats. The AST-120-treated rats showed an increase of creatinine clearance. Urinary protein and indoxyl sulfate excretion in the AST-120-treated rats were also significantly lower than those in the untreated control rats. The ratio of glomerular tuft area to the area of Bowman's capsules (GT/BC) in the AST-120-treated rats was significantly lower than that in the untreated control rats. The degree of glomerular sclerosis and tubulointerstitial fibrosis in the AST-120-treated rats was significantly lower than that in the untreated control rats. Furthermore, there was a significant relationship among the degree of GT/BC, glomerular sclerosis, tubulointerstitial fibrosis and the levels of urinary protein excretion. It appears that AST-120 might decrease the accumulation of s-Cr and s-IS, and prevent glomerular sclerosis in early stage renal failure in the subtotal nephrectomized rats. Copyright (C) 2002 S. Karger AG, Basel.