BETA-ADRENOCEPTOR ADAPTATION TO ACUTE EXERCISE
BETA-ADRENOCEPTOR ADAPTATION TO ACUTE EXERCISE
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DOI：
10.1113/jphysiol.1983.sp014927
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发表时间：
1983-01-01
影响因子：
5.5
通讯作者：
PIDGEON, F
中科院分区：
文献类型：
--
作者：
BUTLER, J;KELLY, JG;PIDGEON, F
剧烈运动对淋巴细胞的影响。- 9例患者肾上腺素受体密度和反应性呈双相。运动后，受体密度开始增加，随后下降到低于运动前的值。与此同时，最大异丙肾上腺素刺激淋巴细胞产生的cAMP在运动结束时大大增加，随后下降。运动结束时看到的增加可能具有重要的功能意义，可能代表了组织对施加在它身上的需求的反应。一段时间后，脱敏过程开始起作用，可能起到保护作用。
The effects of strenuous exercise of lymphocyte .beta.-adrenoceptor density and responsiveness in 9 men were biphasic. There was an initial increase in receptor density, seen immediately after exercise, with a subsequent decline to below pre-exercise values. In parallel, maximum isoprenaline-stimulated cAMP production by lymphocytes was greatly increased at the end of exercise and decreased thereafter. The increases seen at the end of exercise may be of functional significance and may represent a response of the tissue to the demands placed upon it. After a time, a desensitization process takes over, possibly with a protective role.