CUTANEOUS SENSORY RECEPTORS IN THE RAT FOOT
CUTANEOUS SENSORY RECEPTORS IN THE RAT FOOT
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DOI：
10.1152/jn.1993.69.5.1684
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发表时间：
1993-05-01
影响因子：
2.5
通讯作者：
CHUNG, JM
中科院分区：
文献类型：
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作者：
LEEM, JW;WILLIS, WD;CHUNG, JM
1. 在供应大鼠足部皮肤的腓肠神经和足底神经中，共检查了574个皮肤传入单位：399个abeta单位，55个adelta单位和120个c单位。它们的接受场（RF）特性与其他哺乳动物相似。但两种神经的受体类型组成单位不同。样本（n = 160）由g毛（4.1%）、田间（11%）、快速适应（RA; 6%）、缓慢适应I型（SA-I; 7%）和II型（SA-II; 35%）机械感受器组成。足底β -纤维样品（n = 239）由g毛（3%）、RA（35%）、SA-I（30%）、SA-II（24%）和太平洋小体（PC; 8%）机械感受器组成。SA-II单元的rf位于足关节上的有毛和无毛皮肤上。许多SA-II单元对足关节的运动有反应。sa - 1和RA单位的rf体积小，位于趾尖和脚垫的密度高。PC单元对振动非常敏感，并且与其他物种一样具有极大的rf，尽管它们很罕见并且仅在足底神经中发现。野外单元在响应特性和RF分布上与SA-II单元相似。腓特尔-阿德尔塔纤维样本（n = 44）包括伤害感受器（68%）、d -毛发（27%）和冷感受器（5%）。所有取样的足底adelta纤维（n = 11）均为伤害感受器。在阿德尔-伤害感受器中，阿德尔-机械伤害感受器占73%。血清c -纤维样本（n = 85）包括伤害感受器（44%）、c -机械感受器（33%）和冷感受器（21%）。足底c纤维样本（n = 35）包括伤害感受器（77%）和冷感受器（23%）。在腓肠和足底神经纤维中没有发现温暖单位。在c -伤害感受器中，c -机械热伤害感受器占80%。结果表明，除温暖受体外，所有已知类型的皮肤受体都存在于大鼠足部皮肤中。基于RA和sa - 1单元的RFs在趾尖和脚垫上密度较高的事实，认为这些区域可能具有空间辨别能力。也有人认为SA-II受体可能在本体感觉中起作用，因为它们在足关节皮肤上有RFs，并对关节运动作出反应。伤害感受器单位是两种神经中最主要的a-和c -纤维类型。与其他哺乳动物的区别在于，大鼠腓肠神经中c -机械感受器单元是一种相对常见的c -纤维类型，而c -纤维冷单元在这两种神经中都很常见。
1. A total of 574 cutaneous afferent units in the sural and plantar nerves supplying the skin of the rat foot was examined: 399 Abeta-units, 55 Adelta-units, and 120 C-units. Their receptive-field (RF) properties were similar to those described in other mammals. However, the receptor type composition of units was different between the two nerves.2. The sural Abeta-fiber sample (n = 160) consisted of G-hair (4 1%), field (11%), rapidly adapting (RA; 6%), slowly adapting type I (SA-I; 7%), and type II (SA-II; 35%) mechanoreceptors. The plantar Abeta-fiber sample (n = 239) was composed of G-hair (3%), RA (35%), SA-I (30%), SA-II (24%), and Pacinian corpuscle (PC; 8%) mechanoreceptors.3. The RFs of SA-II units were located on both hairy and glabrous skin overlying the foot joints. Many of the SA-II units responded to movement of the footjoints. The RFs of both SA-I and RA units were small in size and located in high density on the toe tips and footpads. PC units were very sensitive to vibration and had extremely large RFs as in other species, although they were rare and found only in the plantar nerve. Field units were similar to SA-II units in response properties and RF distribution.4. The sural Adelta-fiber sample (n = 44) included nociceptors (68%), D-hair (27%), and cold (5%) receptors. All sampled plantar Adelta-fibers (n = 11) were nociceptors. Of Adelta-nociceptor units, Adelta-mechanical nociceptors (73%) were dominant.5. The sural C-fiber sample (n = 85) included nociceptors (44%), C-mechanoreceptors (33%), and cold receptors (21%). The plantar C-fiber sample (n = 35) included nociceptors (77%) and cold receptors (23%). No warm units were found among either the sural or plantar nerve fibers. Of C-nociceptors, C-mechanoheat nociceptors (80%) were dominant.6. The results indicate that all well-known types of cutaneous receptors, except warm receptors, exist in the foot skin of the rat. On the basis of the fact that RFs of RA and SA-I units are in high density on the toe tips and footpads, it is suggested that those regions may have a spatial discriminating capacity. It is also suggested that SA-II receptors may play a role in proprioception, because they have RFs on the skin over foot joints and respond to joint movement.7. Nociceptor units are the most dominant type of Adelta- and C-fibers in both nerves. The distinguishing features from other mammals are that C-mechanoreceptor units are a relatively frequent type of C-fibers in the rat sural nerve, and that C-fiber cold units are common in both nerves.