A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance
A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance
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DOI：
10.1016/j.jid.2020.06.019
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发表时间：
2021-01-24
影响因子：
6.5
通讯作者：
Piguet, Vincent
中科院分区：
文献类型：
--
作者：
Frew, John W.;Marzano, Angelo V.;Piguet, Vincent
本系统综述确定并批判性地评估了化脓性汗腺炎（HS）新的有希望的治疗靶点的机制和临床证据。这些靶点的证据主要基于观察数据，有限的离体和临床试验的转化数据。一些使用IL-1、IL-23、IL-17、补体和Jak抑制的安慰剂对照研究已经完成或正在进行中，尽管在一些参与者亚群中存在安慰剂反应率升高和临床评分有效性问题。发现了知识空白，为未来HS的机制研究指明了方向，包括更全面的疾病炎症内型分析。
This systematic review identifies and critically evaluates the mechanistic and clinical evidence of new promising therapeutic targets in hidradenitis suppurativa (HS). Evidence for these targets is largely based on observational data with limited ex vivo and translational data from clinical trials. A number of placebo-controlled studies have been completed or are underway utilizing IL-1, IL-23, IL-17, complement, and Jak inhibition, although there is concern regarding elevated placebo response rates and the questionable validity of clinical scores in some participant subsets. Knowledge gaps are identified suggesting a direction for future mechanistic studies in HS, including more comprehensive inflammatory endotype profiling of disease.