Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder.
Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder.
复制标题
成人创伤后应激障碍的大脑、头骨和脑脊液容量。
DOI：
10.1002/jts.20241
复制
发表时间：
2007
影响因子：
3.3
通讯作者：
Stewart,Lorraine
中科院分区：
文献类型：
--
作者：
Woodward,StevenH;Kaloupek,DannyG;Streeter,ChrisC;Kimble,MatthewO;Reiss,AllanL;Eliez,Stephan;Wald,LawrenceL;Renshaw,PerryF;Frederick,BlaiseB;Lane,Barton;Sheikh,JavaidI;Stegman,WendyK;Kutter,CatherineJ;Stewart,Lorraine
患有虐待相关创伤后应激障碍（PTSD）的儿童和青少年表现出比对照组更小的颅内组织体积。在颅内组织体积和虐待开始的年龄之间也观察到线性关系。作者探讨了99名退伍军人的成年PTSD、早期创伤和脑容量之间的关系。开发了基于骨的颅体积估计，以调整体型的变化。创伤后应激障碍与脑组织体积较小无关，但与脑脊液（CSF）和颅体积较小有关。这些发现与酒精中毒和衰老对脑组织和脑脊液容量的预期影响同时发生。研究结果表明，成年创伤后PTSD患者和非PTSD患者在早期发育上存在差异。
Children and adolescents with maltreatment‐related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone‐based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co‐occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.