Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity
Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity
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DOI：
10.1021/acs.orglett.6b03057
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发表时间：
2016-11-18
期刊：
影响因子：
5.2
通讯作者：
Oshima, Yoshiteru
中科院分区：
文献类型：
--
作者：
Kikuchi, Haruhisa;Ichinohe, Keisuke;Oshima, Yoshiteru
环烯醚萜共轭吲哚类化合物的库构建从多样性增强的提取物，这构成了一种方法，增加天然产物的化学多样性的化合物，通过结合天然产物化学和多样性导向的合成。该文库的药理学筛选揭示了可用于开发小分子免疫检查点抑制剂的种子化合物。
A library of iridoid-conjugated indole alkaloid-like compounds was constructed from diversity-enhanced extracts, which constitutes an approach for increasing the chemical diversity of natural-product-like compounds by combining natural product chemistry and diversity-oriented synthesis. Pharmacological screening of the library revealed a seed compound that can be used for the development of small molecular immune checkpoint inhibitors.