Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
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DOI：
10.1073/pnas.0400285101
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发表时间：
2004-05-04
影响因子：
11.1
通讯作者：
Barnes, CA
中科院分区：
文献类型：
--
作者：
Small, SA;Chawla, MK;Barnes, CA
海马体结构包含一组不同的神经元，这些神经元被组织成不同的解剖亚区。每个海马区表达一个独特的分子图谱，说明它们对记忆功能障碍机制的不同脆弱性。然而，目前还不清楚哪个海马区对年龄增长的影响最敏感。在这里，我们通过使用不同的成像技术来研究这个问题，每种技术都评估不同的神经功能相关性。首先，我们使用核磁共振成像绘制了幼年和老年恒河猴海马亚区的脑血容量图，脑血容量是基础代谢的既定相关性。其次，我们用原位杂交技术定位了青年和老年大鼠海马亚区Arc的表达。ARC是一种即刻早期基因，以行为依赖的方式被激活，并与棘波活动相关。结果表明，齿状回是海马区对增龄影响最敏感的区域，这与先前的研究一起建立了跨物种的共识。这种模式分离了与年龄相关的海马体功能障碍的部位，并将正常衰老与阿尔茨海默病区分开来。
The hippocampal formation contains a distinct population of neurons organized into separate anatomical subregions. Each hippocampal subregion expresses a unique molecular profile accounting for their differential vulnerability to mechanisms of memory dysfunction. Nevertheless, it remains unclear which hippocampal subregion is most sensitive to the effects of advancing age. Here we investigate this question by using separate imaging techniques, each assessing different correlates of neuronal function. First, we used MRI to map cerebral blood volume, an established correlate of basal metabolism, in the hippocampal subregions of young and old rhesus monkeys. Second, we used in situ hybridization to map Arc expression in the hippocampal subregions of young and old rats. Arc is an immediate early gene that is activated in a behavior-dependent manner and is correlated with spike activity. Results show that the dentate gyrus is the hippocampal subregion most sensitive to the effects of advancing age, which together with prior studies establishes a cross-species consensus. This pattern isolates the locus of age-related hippocampal dysfunction and differentiates normal aging from Alzheimer's disease.