Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells.
Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells.
复制标题
神经调节蛋白在苔藓纤维和小脑颗粒细胞之间突触发生中的作用。
DOI：
10.1002/(sici)1097-4547(20000301)59:5
复制
发表时间：
2000
影响因子：
4.2
通讯作者：
Hashikawa,T
中科院分区：
文献类型：
--
作者：
Ozaki,M;Tohyama,K;Kishida,H;Buonanno,A;Yano,R;Hashikawa,T
Neuregulins (NRGs), a large group of structurally related signaling proteins, are likely to have important roles in the development, maintenance and repair of the nervous system and other selected tissues. We have demonstrated, by using the major form of NRG cloned from the mouse cerebellum that both the soluble form and the membrane anchored form of NRG may serve different functions in synaptogenesis. The soluble form of NRG was produced by proteolytic cleavage of the membrane anchored form of NRG. The proteolytic cleavage was promoted by protein kinase activation. The cleaved form of NRG trans‐synaptically regulated the expression of the NMDA (N‐methyl‐D‐aspartate) receptor subunit NR2C as neurally‐derived factors, whereas the membrane anchored form of NRG showed a homophilic binding activity between NRGβ1s. In adult mice the membrane anchored form of NRG was concentrated in neuro‐terminals of both granule cells and pontocerebellar mossy fibers. The fact that NRG can be functionally viewed as cell recognition molecules as well as neurotrophic agents suggests new possibilities for the important class of molecules. J. Neurosci. Res. 59:612–623, 2000 © 2000 Wiley‐Liss, Inc.
