Eye dryness sensations after refractive surgery: Impaired tear secretion or "phantom" cornea?
Eye dryness sensations after refractive surgery: Impaired tear secretion or "phantom" cornea?
复制标题
DOI：
10.3928/1081-597x-20070601-11
复制
发表时间：
2007-06-01
影响因子：
2.4
通讯作者：
Belmonte, Carlos
中科院分区：
文献类型：
--
作者：
Belmonte, Carlos
角膜由各种功能类型的感觉神经纤维丰富地支配。当受到刺激时，这些纤维会唤起意识。不同质量的感觉，包括眼睛干燥、不适和疼痛。屈光手术涉及对角膜神经的不同程度的损伤。这导致受损和再生神经纤维处膜离子通道的表达改变，从而引起异常自发和刺激诱发的神经脉冲放电。据推测，这些异常的感觉放电被大脑解读为眼表干燥。这可以解释光折射手术后眼睛干燥感的高发生率，尽管泪液分泌通常受到适度干扰，但大量患者都会经历这种情况。因此，减少受损神经异常活动的药物可能是屈光手术后眼干燥感觉的治疗选择。
The cornea is richly innervated by various functional types of sensory nerve fibers. When stimulated, these fibers evoke conscious. sensations of different quality including ocular dryness, discomfort, and pain. Refractive surgery involves a variable degree of damage to corneal nerves. This leads to an altered expression of membrane ion channels at the injured and regenerating nerve fibers, giving rise to aberrant spontaneous and stimulus-evoked nerve impulse firing. It is speculated that these abnormal sensory discharges are read by the brain as ocular surface dryness. This would explain the high incidence of eye dryness sensations after photorefractive surgery, which are experienced by a large number of patients despite the often modest disturbance of tear secretion. Therefore, drugs that reduce abnormal activity in injured nerves may represent a therapeutic alternative for eye dryness sensations after refractive surgery.