Suppression of fever at term of pregnancy
Suppression of fever at term of pregnancy
复制标题
妊娠期发烧的抑制
作者：
N. Kasting;W. Veale;K. Cooper
新生人类在暴露于各种传染性病原体1 -3后通常不会出现发热，新生羔羊也类似，因为它们在生命的最初几天内不会对细菌内毒素攻击作出反应而出现发热4。缺乏发热反应被认为是由于羔羊需要一个“致敏”过程，或发热过程的某些方面不成熟5，6。新生豚鼠和家兔在出生后早期也不会发热或对内毒素激发反应减弱7，8。我们已经检查了妊娠母羊在出生时和接近出生时对热原的反应，因为尽管它们在妊娠期间会发热9，但它们在足月时对内毒素的反应尚未研究。我们在这里报告，由细菌内毒素或内源性热原引起的发热反应被抑制在母羊的一段时间内，从产后2至5天延伸到产后几个小时。
THE newborn human is often unable to develop a fever following exposure to various infectious agents1–3 and newborn lambs are similar, in that they do not develop a fever in response to a bacterial endotoxin challenge in the first few days of life4. Lack of the febrile response is thought to be due to the need for a process of ‘sensitisation’ of the lambs, or to the immaturity of some aspect of the fever-production process5,6. Newborn guinea pigs and rabbits also, do not become febrile or show a diminished response to a challenge with endotoxin during early postnatal life7,8. We have examined the response of the pregnant ewe to pyrogens at and near the time of birth, for although they become febrile during pregnancy9, their response to endotoxin at term has not been studied. We report here that the febrile response induced by a bacterial endotoxin or by endogenous pyrogen is suppressed in the ewe for a period extending from 2 to 5 d prepartum to several hours postpartum.