Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate.
Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate.
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DOI：
10.1016/j.colsurfb.2012.01.038
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发表时间：
2012-06
期刊：
影响因子：
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通讯作者：
Hisatomo Suzuki;Lifu Li;T. Nakaji-Hirabayashi;H. Kitano;K. Ohno;K. Matsuoka;Yoshiyuki Saruwatari
中科院分区：
文献类型：
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作者：
Hisatomo Suzuki;Lifu Li;T. Nakaji-Hirabayashi;H. Kitano;K. Ohno;K. Matsuoka;Yoshiyuki Saruwatari
以2，2‘-偶氮二异丁腈为引发剂，在乙醇中合成了两性离子单体羧甲基甜菜碱(CMB)和3-甲基丙烯酰氧丙基三甲氧基硅烷(CMB)的无规共聚物。将共聚物的乙醇溶液与玻璃板孵育，得到厚度约为2-3 nm的共聚物层。共聚物修饰的玻璃基板在水中浸泡后具有很强的亲水性，并对蛋白质的非特异性吸附表现出抵抗能力，并且抵抗程度随着共聚物中CMB残基含量的增加而增加并趋于平缓。共聚物层的表面修饰也强烈地抑制了各种细胞在玻璃基板上的粘附性。在膜表面进一步引入PolyCMB接枝链，增强了由于空间位阻使细胞接近膜而抑制了细胞的黏附。展示了两性离子聚合物层和接枝链的组合对金属氧化物固体表面提供抗生物污垢性能的有效性。
A random copolymer of zwitterionic monomer, carboxymethylbetaine (CMB), and 3-methacryloyloxypropyl trimethoxysilane was prepared in ethanol using 2,2′-azobisisobutyronitrile as initiator. The incubation of ethanol solution of the copolymer with a glass plate gave a layer of the copolymer with a thickness of about 2–3nm. The copolymer-modified glass substrate became highly hydrophilic upon immersion in water, and showed a resistance against non-specific adsorption of proteins, and the degree of resistance increased with the content of CMB residues in the copolymer and leveled off. The adhesion of various cells to the glass substrate was also strongly suppressed by the surface modification with the copolymer layer. Further introduction of PolyCMB graft chains on the surface of the layer enhanced the suppression of cell adhesion due to the steric hindrance for the cells to approach the layer. The usefulness of the combination of zwitterionic polymer layer and graft chains to afford anti-biofouling properties to a solid surface of metal oxides was shown.