Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
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DOI：
10.1084/jem.169.4.1199
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发表时间：
1989-04-01
期刊：
影响因子：
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通讯作者：
Koszinowski UH
中科院分区：
文献类型：
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作者：
Jonjić S;Mutter W;Weiland F;Reddehase MJ;Koszinowski UH
我们建立了一个小鼠模型系统，以探索CD 4亚群缺陷型宿主科普巨细胞病毒感染的能力，并报告了三个结果。第一，T淋巴细胞的CD 8亚群的抗病毒应答不仅可以启动，而且可以维持很长一段时间，尽管持续缺乏CD 4亚群，而抗病毒抗体的产生被证明严格依赖于由CD 4亚群提供的帮助。第二，CD 4-CD 8- T淋巴细胞在抵抗感染的防御中没有任何功能，因为CD 4亚群的耗竭导致其积累到一个新的亚群。这种新出现的亚群不能替代CD 4 + T淋巴细胞为B淋巴细胞提供帮助，也不能有效控制病毒在宿主组织中的传播。只要这些细胞在产生和维持CD 8亚群介导的应答中的功能没有被证明是错误的，就需要注意CD 8亚群的自主性。第三，即使有延迟，在CD 4亚群缺陷宿主中产生的CD 8+效应细胞能够清除重要组织的生产性感染，并将无症状的持续感染限制在唾液腺组织中的腺泡腺上皮细胞。
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.