Decreased demands on cognitive control reveal the neural processing benefits of forgetting
Decreased demands on cognitive control reveal the neural processing benefits of forgetting
复制标题
DOI：
10.1038/nn1918
复制
发表时间：
2007-07-01
影响因子：
25
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
Kuhl, Brice A.;Dudukovic, Nicole M.;Wagner, Anthony D.
记忆通常需要在与无关记忆的竞争中选择与目标相关的记忆。虽然选择目标记忆而不是竞争记忆（增加对竞争记忆的遗忘）是有代价的，但在这里，我们报告了遗忘的适应性益处的神经证据，即在未来的记忆行为中减少对认知控制的需求。功能磁共振成像在选择性检索显示，目标记忆的重复检索伴随着动态减少的功能耦合认知控制机制，检测（前扣带皮层）和解决（背外侧和腹外侧前额叶皮层）记忆竞争的参与。引人注目的是，回归分析显示，这种前额叶脱离追踪了竞争性记忆被遗忘的程度;对竞争性记忆的遗忘程度越高，在记忆目标时对前额叶皮层的需求就越低。这些发现表明，虽然遗忘可能令人沮丧，但记忆可能是自适应的，因为遗忘赋予神经处理益处。
Remembering often requires the selection of goal-relevant memories in the face of competition from irrelevant memories. Although there is a cost of selecting target memories over competing memories (increased forgetting of the competing memories), here we report neural evidence for the adaptive benefits of forgetting-namely, reduced demands on cognitive control during future acts of remembering. Functional magnetic resonance imaging during selective retrieval showed that repeated retrieval of target memories was accompanied by dynamic reductions in the engagement of functionally coupled cognitive control mechanisms that detect (anterior cingulate cortex) and resolve (dorsolateral and ventrolateral prefrontal cortex) mnemonic competition. Strikingly, regression analyses revealed that this prefrontal disengagement tracked the extent to which competing memories were forgotten; greater forgetting of competing memories was associated with a greater decline in demands on prefrontal cortex during target remembering. These findings indicate that, although forgetting can be frustrating, memory might be adaptive because forgetting confers neural processing benefits.