A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility
A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility
复制标题
DOI：
10.1038/onc.2011.161
复制
发表时间：
2011-11-01
期刊：
影响因子：
8
通讯作者：
Wong, N.
中科院分区：
文献类型：
--
作者：
Leung, W. K. C.;Ching, A. K. K.;Wong, N.
PFTK1基因编码一种与cdc2相关的丝氨酸/苏氨酸蛋白激酶，该激酶已被证明在肝细胞癌（HCC）中具有细胞迁移特性。然而，PFTK1促进HCC运动的预后价值和生物学机制在很大程度上仍然未知。在这里，我们通过组织芯片显示原发性HCC肿瘤（n = 133/180）中常见的PFTK1上调与早期发病显著相关(
The PFTK1 gene encodes a cdc2-related serine/threonine protein kinase that has been shown to confer cell migratory properties in hepatocellular carcinoma (HCC). However, the prognostic value and biological mechanism by which PFTK1 promotes HCC motility remain largely unknown. Here, we showed from tissue microarray that common upregulations of PFTK1 in primary HCC tumors (n = 133/180) correlated significantly with early age onset (