Temporal changes and control variables of growth differentiation factor 15 levels during the first week of life in hospitalised newborn infants
Temporal changes and control variables of growth differentiation factor 15 levels during the first week of life in hospitalised newborn infants
复制标题
DOI：
10.1016/j.mito.2021.09.002
复制
发表时间：
2021-09-25
期刊：
影响因子：
4.4
通讯作者：
Koga, Yasutoshi
中科院分区：
文献类型：
--
作者：
Kinoshita, Masahiro;Yatsuga, Shuichi;Koga, Yasutoshi
血清生长分化因子15 （GDF15）是线粒体疾病的有用生物标志物；它在新生儿中的效用尚不清楚。为了研究出生后第一周内GDF15的时间变化，并确定其潜在的控制变量，我们从18名新生儿中采集了血液样本。GDF15水平在出生后第一周内下降到脐带血水平的35%左右，与出生年龄和出生体重z评分呈负相关，但与n端脑钠肽前体和乳酸水平呈正相关。GDF15水平可能反映了出生后向有氧代谢过渡的进程。
Serum growth differentiation factor 15 (GDF15) is a useful biomarker of mitochondrial diseases; its utility in newborns remains unknown. To investigate the temporal change in GDF15 within the first week of life, and to identify its potential control variables, blood samples were obtained from 18 newborns. The GDF15 levels declined to approximately 35% of the cord blood levels within the first week of life and were negatively correlated with postnatal age and Z-score of birth weight but were positively correlated with N-terminal probrain natriuretic peptide and lactate levels. GDF15 levels may reflect the progress of postnatal transition to aerobic metabolism.