B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis.
B7-H4 Polymorphism Influences the Prevalence of Diabetes Mellitus and Pro-Atherogenic Dyslipidemia in Patients with Psoriasis.
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DOI：
10.3390/jcm11216235
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发表时间：
2022-10-22
影响因子：
3.9
通讯作者：
Yan K
中科院分区：
文献类型：
--
作者：
Yang W;Huang Q;Han L;Wang B;Yawalkar N;Zhang Z;Yan K
背景：共抑制分子B7-H4位于与1型糖尿病（T1 D）易感性相关的基因组区域。然而，B7-H4与糖代谢紊乱和血脂异常的相关性尚未研究。目的：探讨B7-H4基因多态性与银屑病患者糖尿病（DM）及血脂异常的关系。方法：在这项单中心横断面研究中，我们招募了265例接受甲氨蝶呤（MTX）治疗的银屑病患者。对B7-H4的13个单核苷酸多态性（SNPs）进行了基因分型。在基线和第12周测量血清总胆固醇（TC）、甘油三酯（TG）、脂蛋白（a）（LP（a））、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白（LDL）、载脂蛋白A1（ApoA 1）和载脂蛋白B（ApoB）水平。结果如下：与AA或AG基因型携带者相比，B7-H4中rs 12025144 GG基因型携带者的DM患病率更高（57.14%比17.71%比18.67%，p = 0.0018），并且糖尿病患者对MTX的反应较差（p < 0.05）。rs 2066398的AG基因型与较高水平的促动脉粥样硬化脂质相关。MTX显著下调rs 2066398 AA基因型携带者的抗动脉粥样硬化脂质ApoA 1水平。结论：B7-H4基因型rs 12025144和rs 2066398分别与银屑病患者DM和血脂异常的高患病率相关。
Background: The co-inhibitory molecule B7-H4 is located in the genomic regions associated with type 1 diabetes (T1D) susceptibility. However, the correlation of B7-H4 with glycometabolism and dyslipidemia has never been studied. Objective: To explore the influence of B7-H4 polymorphism on the prevalence of diabetes mellitus (DM) and dyslipidemia in psoriasis. Methods: In this single-center cross-sectional study, we recruited 265 psoriatic patients receiving methotrexate (MTX) treatment. Thirteen single-nucleotide polymorphisms (SNPs) in B7-H4 were genotyped. Serum levels of total cholesterol (TC), triglycerides (TG), lipoprotein (a) (LP(a)), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB) were measured at baseline and week 12. Results: The GG genotype carriers of rs12025144 in B7-H4 had a higher prevalence of DM (57.14% vs. 17.71% vs. 18.67%, p = 0.0018), and had a poorer response to MTX in diabetic patients (p < 0.05), compared with AA or AG genotype carriers. The AG genotype of rs2066398 was associated with higher levels of pro-atherogenic lipids. MTX significantly downregulated the level of anti-atherogenic lipid ApoA1 in AA genotype carriers of rs2066398. Conclusions: The genotypes rs12025144 and rs2066398 in B7-H4 were correlated with a higher prevalence of DM and dyslipidemia in psoriasis, respectively.
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DOI：
10.1111/jdv.12001
发表时间：
2013-10-01
影响因子：
9.2
作者：
Kumar, S.;Han, J.;Qureshi, A. A.
通讯作者：
Qureshi, A. A.
影响因子：
7.7
作者：
Penha-Gonçalves, C;Moule, C;Wicker, LS
通讯作者：
Wicker, LS
DOI：
10.4049/jimmunol.1003523
发表时间：
2011-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rainbow DB;Moule C;Fraser HI;Clark J;Howlett SK;Burren O;Christensen M;Moody V;Steward CA;Mohammed JP;Fusakio ME;Masteller EL;Finger EB;Houchins JP;Naf D;Koentgen F;Ridgway WM;Todd JA;Bluestone JA;Peterson LB;Mattner J;Wicker LS
通讯作者：
Wicker LS
影响因子：
4.1
作者：
DeOliveira, Caroline Candida;Acedo, Simone Coghetto;Gambero, Alessandra
通讯作者：
Gambero, Alessandra
影响因子：
7.7
作者：
Radichev IA;Maneva-Radicheva LV;Amatya C;Parker C;Ellefson J;Wasserfall C;Atkinson M;Burn P;Savinov AY
通讯作者：
Savinov AY