Use of Three-Dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery
Use of Three-Dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery
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DOI：
10.1002/anie.201509752
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发表时间：
2016-03-24
影响因子：
16.6
通讯作者：
Akashi, Mitsuru
中科院分区：
文献类型：
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作者：
Chetprayoon, Paninee;Matsusaki, Michiya;Akashi, Mitsuru
纳米材料已广泛应用于生物医学领域，并可能在不久的将来成为不可或缺的。然而，由于难以通过使用单细胞体外来优化3D环境中的体内生物学行为，因此在动物模型中存在许多失败。使用反映细胞类型的3D位置的3D人体组织模型的体外预测系统可能有助于更好地了解纳米材料的生物学特性，以优化其功能。在这里，我们证明了三维工程人体动脉模型的潜在能力，用于体外预测药物输送纳米颗粒的体内行为。这些模型使得能够优化纳米颗粒的组成和尺寸，用于靶向和治疗动脉粥样硬化。动脉粥样硬化小鼠的体内实验表明，体外优化的纳米颗粒具有良好的生物学特性和潜在的治疗效果。
Nanomaterials have been widely used for applications in biomedical fields and could become indispensable in the near future. However, since it is difficult to optimize invivo biological behavior in a 3D environment by using a single cell invitro, there have been many failures in animal models. Invitro prediction systems using 3D human-tissue models reflecting the 3D location of cell types may be useful to better understand the biological characteristics of nanomaterials for optimization of their function. Herein we demonstrate the potential ability of 3D engineered human-arterial models for invitro prediction of the invivo behavior of nanoparticles for drug delivery. These models enabled optimization of the composition and size of the nanoparticles for targeting and treatment efficacy for atherosclerosis. Invivo experiments with atherosclerotic mice suggested excellent biological characteristics and potential treatment effects of the nanoparticles optimized in vitro.