The regulatory mechanisms of NG2/CSPG4 expression.
The regulatory mechanisms of NG2/CSPG4 expression.
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DOI：
10.1186/s11658-017-0035-3
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发表时间：
2017
影响因子：
8.3
通讯作者：
Laschke MW
中科院分区：
文献类型：
--
作者：
Ampofo E;Schmitt BM;Menger MD;Laschke MW
神经胶质抗原2（NG 2），也称为硫酸软骨素蛋白聚糖4（CSPG 4），是一种表面I型跨膜核心蛋白聚糖，其在细胞存活、迁移和血管生成中至关重要。NG 2经常被用作某些细胞类型的鉴定和表征的标志物，但对其表达的调控机制知之甚少。在这篇综述中，我们提供的证据表明，NG 2表达的调节是炎症和缺氧的基础，并介导的甲基转移酶，转录因子，包括Sp1，配对盒（Pax）3和Egr-1，和microRNA miR 129 -2。这些调节因子决定性地决定NG 2介导的细胞过程，如中枢神经系统（CNS）中的神经胶质瘢痕形成或肿瘤生长和转移。因此，它们是建立治疗CNS损伤、癌症和这些类型的其他病症的基于NG 2的新型治疗策略的潜在靶标。
Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogenesis. NG2 is frequently used as a marker for the identification and characterization of certain cell types, but little is known about the mechanisms regulating its expression. In this review, we provide evidence that the regulation of NG2 expression underlies inflammation and hypoxia and is mediated by methyltransferases, transcription factors, including Sp1, paired box (Pax) 3 and Egr-1, and the microRNA miR129-2. These regulatory factors crucially determine NG2-mediated cellular processes such as glial scar formation in the central nervous system (CNS) or tumor growth and metastasis. Therefore, they are potential targets for the establishment of novel NG2-based therapeutic strategies in the treatment of CNS injuries, cancer and other conditions of these types.