Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease
Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease
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DOI：
10.1046/j.1365-2249.1997.d01-991.x
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发表时间：
1997-04-01
影响因子：
4.6
通讯作者：
Tonietti, G
中科院分区：
文献类型：
--
作者：
Giacomelli, R;Cipriani, P;Tonietti, G
活化的Th2淋巴细胞表达表面分子CD30并释放可溶形式的相同分子，其可在体内和体外检测。在本研究中，高水平的可溶性CD 30被发现在SSc患者的外周血中，并与皮肤评分和红细胞沉降率（ESR）检测到显着相关性。此外，我们观察到较高的自发释放可溶性CD 30的未刺激的培养物的上清液中的外周血单核细胞从我们的患者相比，健康对照。综上所述，这些数据表明，可能参与的Th2细胞在SSc的免疫发病机制，和剂量的CD30可溶性外周血中可能有助于以下疾病的结果。
Activated Th2 lymphocytes express the surface molecule CD30 and release a soluble form of the same molecule which can be detected both in vivo and in vitro. In the present study, high levels of soluble CD30 were found in the peripheral blood of patients with SSc, and a significant correlation with skin score and erythrocyte sedimentation rate (ESR) was detected. Furthermore, we observed a higher spontaneous release of soluble CD30 in the supernatants of unstimulated cultures of peripheral blood mononuclear cells from our patients compared with healthy controls. Taken together, these data suggest a possible involvement of Th2 cells in the immunopathogenesis of SSc, and the dosage of CD30 soluble in the peripheral blood may be helpful in following the outcome of the disease.