Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts
Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts
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DOI：
10.1007/s11046-006-0062-5
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发表时间：
2006-11-01
期刊：
影响因子：
5.5
通讯作者：
Wengenack, Nancy L.
中科院分区：
文献类型：
--
作者：
Blair, Janis E.;Coakley, Brandon;Wengenack, Nancy L.
血清学研究是球孢子菌病患者临床评价和随访的重要诊断工具。许多类型的血清学测试是可用的，包括免疫扩散，酶免疫测定和补体固定。我们对298名免疫正常和62名有症状感染的免疫抑制患者从球孢子菌病发病起12个月内的1797项血清学检测结果进行了回顾性分析。以症状开始为参考点，我们绘制了两组随时间的阳性或阴性血清学结果。与免疫正常组相比，免疫抑制的人在球孢子菌病症状出现后的第一年里，每种类型的血清阳性率都较低，尽管许多结果没有达到统计学意义。结合这些试验的结果增加了免疫功能低下患者血清学评估的敏感性。免疫抑制的人有能力对球孢子菌病产生血清学反应，但在某些情况下，可能需要多种方法来提高检测。
Serologic studies are an important diagnostic tool in the clinical evaluation and follow-up of persons with coccidioidomycosis. Numerous types of serologic tests are available, including immunodiffusion, enzyme immunoassay, and complement fixation. We conducted a retrospective review of the results of 1,797 serologic tests spanning 12 months from the onset of coccidioidomycosis in 298 immunocompetent and 62 immunosuppressed persons with symptomatic infection. Using the onset of symptoms as a reference point, we plotted the positive or negative serologic results over time for both groups. Compared with the immunocompetent group, immunosuppressed persons had lower rates of seropositivity for every type of test during the first year after onset of symptoms for coccidioidomycosis, although many results did not achieve statistical significance. Combining the results of these tests increased the sensitivity of the serologic evaluation in immunocompromised patients. Immunosuppressed persons have the ability to mount a serologic response to coccidioidomycosis, but in some circumstances, multiple methods may be required to improve detection.