SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE MULTIPLE-SCLEROSIS LESIONS
SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN ACUTE MULTIPLE-SCLEROSIS LESIONS
复制标题
DOI：
10.1093/brain/117.1.49
复制
发表时间：
1994-02-01
期刊：
影响因子：
14.5
通讯作者：
MCDONALD, WI
中科院分区：
文献类型：
--
作者：
DAVIE, CA;HAWKINS, CP;MCDONALD, WI
对8例多发性硬化症患者进行了连续质子磁共振波谱(MRS)检查，每隔1-2个月进行一次。MRS来自急性病变(感兴趣体积4-12毫升)，表现为Gd-二乙烯三胺五乙酸强化，以及类似体积的正常白质，出现在病变侧边和头皮附近。术后随访4~9个月，平均6个月。急性强化病变的短回声频谱总是在下午0.9和1.3时出现大的共振。与正常外观白质和健康年龄的对照组相比，这些峰值不是头皮脂肪体素污染的结果。这些共振，可能代表髓鞘分解的脂质产物，在病变中被检测到，这些病变已经增强了
Serial proton magnetic resonance spectroscopy (MRS), was carried out at 1-2 monthly intervals on eight patients with multiple sclerosis who presented with evidence of a large acute cerebral white matter lesion. An MRS was obtained from acute lesions (volumes of interest 4-12 ml), which at presentation showed gadolinium-diethylenetriamine penta-acetic acid enhancement, and from similar volumes of normal appearing white matter lateral to the lesion and nearer the scalp. Followup ranged from 4 to 9 months (mean 6 months). Short echo spectra from acute enhancing lesions invariably showed the presence of large resonances at 0.9 and 1.3 p.p.m. compared with normal appearing white matter and healthy age marched controls, indicating that these peaks were nor the result of voxel contamination from scalp fat. These resonances, which probably represent lipid products of myelin breakdown, were detected in lesions which had been enhancing for