A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer
A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer
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DOI：
10.1039/d2nh00283c
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发表时间：
2022-08-02
影响因子：
9.7
通讯作者：
Zhu, Xingjun
中科院分区：
文献类型：
--
作者：
Hu, Qian;Kong, Na;Zhu, Xingjun
镧系元素发光纳米温度计(LNT)提供了显微、高灵敏度和可视化的光学信号来报告温度信息，这在生物医学中特别有用，以实现精确的诊断和治疗。然而，在第二和第三近红外(NIR-II/III)生物窗口的长波区有效发射的LNTs仍然是有限的，这更有利于活体测温。在这里，我们提出了一种以Tm3+和Nd3+离子为发射体的稀土掺杂纳米复合材料，其工作波长超过1200 nm，从而构建了双比例LNT。利用稀土离子之间的交叉弛豫过程，建立了一种增强Tm3+近红外发射的策略，用于基于生物成像的活体温度检测。纳米复合材料中包含的双比率探针具有在纳米尺度上监测温差和热传递的潜力，这将有助于在热疗和其他生物医学应用中更精确地调节加热操作。这项工作不仅为体内温度传感提供了有力的工具，而且为构建高效的近红外发光纳米材料提供了一种更广泛的生物应用方法。
Lanthanide luminescence nanothermometers (LNTs) provide microscopic, highly sensitive, and visualizable optical signals for reporting temperature information, which is particularly useful in biomedicine to achieve precise diagnosis and therapy. However, LNTs with efficient emissions at the long-wavelength region of the second and the third near-infrared (NIR-II/III) biological window, which is more favourable for in vivo thermometry, are still limited. Herein, we present a lanthanide-doped nanocomposite with Tm3+ and Nd3+ ions as emitters working beyond 1200 nm to construct a dual ratiometric LNT. The cross-relaxation processes among lanthanide ions are employed to establish a strategy to enhance the NIR emissions of Tm3+ for bioimaging-based temperature detection in vivo. The dual ratiometric probes included in the nanocomposite have potential in monitoring the temperature difference and heat transfer at the nanoscale, which would be useful in modulating the heating operation more precisely during thermal therapy and other biomedical applications. This work not only provides a powerful tool for temperature sensing in vivo but also proposes a method to build high-efficiency NIR-II/III lanthanide luminescent nanomaterials for broader bio-applications.