Alternative Polyadenylation in Human Diseases.
Alternative Polyadenylation in Human Diseases.
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DOI：
10.3803/enm.2017.32.4.413
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Yong J
中科院分区：
文献类型：
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作者：
Chang JW;Yeh HS;Yong J
在mRNA前体加工过程中，通过改变多聚腺苷酸化位点的使用，产生了不同长度的信使RNA（mRNA）3′-非翻译区。它在所有真核生物中普遍存在，并已成为控制基因表达的关键机制。选择性多聚腺苷酸化（阿帕）在细胞生长、增殖和分化中起着重要作用。本文综述了阿帕在多种疾病模型中与细胞代谢、mRNA加工和蛋白质多样性等生理条件相关的功能。我们还讨论了阿帕调控的分子机制，如mRNA加工因子和RNA结合蛋白的浓度变化，以及细胞信号通路下的整体转录组变化。
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.