Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment
Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment
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DOI：
10.1055/s-2007-1004594
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发表时间：
2008-03-01
影响因子：
4.3
通讯作者：
Deuschle, M.
中科院分区：
文献类型：
--
作者：
Hellweg, R.;Ziegenhorn, A.;Deuschle, M.
简介：应激、糖皮质激素和抗抑郁治疗可调节脑源性神经营养因子（BDNF）和神经生长因子（NGF）的表达。最近的研究表明，血清BDNF浓度降低抑郁症和成功的抗抑郁治疗导致血清BDNF concentration.Methods的增加：我们研究了抑郁症患者接受标准化的抗抑郁治疗，无论是150毫克阿米替林（n=20）或40毫克帕罗西汀（n = 20）为36天的前瞻性设计。血清神经营养因子和唾液皮质醇的浓度变化，在抗抑郁治疗进行了assessed.Results：独立的临床疗效有一个显着的“治疗”的“药物”的相互作用对BDNF血清浓度的影响，表明下降了12%的脑源性神经营养因子帕罗西汀治疗的患者，而阿米替林治疗的患者增加了13%。两种抗抑郁药均未改变NGF浓度。皮质醇和神经营养因子浓度的变化是不相关的。讨论：BDNF血清浓度的变化作为抗抑郁药治疗的结果取决于抗抑郁药，而不是抗抑郁药治疗的反应的一般特征。
Introduction: Stress, glucocorticoids and antidepressant treatment have been found to modulate the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Recent research suggests that serum BDNF concentration is reduced in depression and that successful antidepressant treatment leads to an increase in serum BDNF concentration.Methods: We studied depressed patients receiving a standardized antidepressant treatment with either 150mg amitriptyline (n=20) or 40 mg paroxetine (n = 20) for 36 days in a prospective design. Changes in the concentrations of serum neurotrophins and salivary cortisol in response to antidepressant treatment were assessed.Results: Independent of clinical efficacy there was a significant 'treatment' by 'medication' interaction effect on BDNF serum concentrations that indicated a decline of BDNF by 12% in paroxetine-treated patients while there was an increase by 13% in amitriptyline-treated patients. Neither antidepressant altered NGF concentrations. The changes in cortisol and neurotrophin concentrations were not related.Discussion: Changes in BDNF serum concentrations as a result of antidepressant therapy depend on the antidepressant instead of being a general characteristic of response to antidepressant treatment.