Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography
Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography
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DOI：
10.1167/iovs.09-5035
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发表时间：
2010-12-01
影响因子：
4.4
通讯作者：
Kook, Michael S.
中科院分区：
文献类型：
--
作者：
Cho, Jung Woo;Sung, Kyung Rim;Kook, Michael S.
目的。目的探讨标准自动视野计(SAP)测量的视野(VF)平均敏感度(MS)与光谱域光学相干断层扫描(SD-OCT)测量的黄斑神经节细胞复合体厚度(GCCT)之间的关系。分别用NHM4(RNFL 1)和RNFL 3.45(RNFL 2)模式测量视网膜神经纤维层厚度(PRNFLT)和节细胞复合体扫描确定的GCCT。用分贝(分贝)和1/L标尺记录MS。结果在线性回归分析中，MS与GCC整体厚度(r=0.445)和部门厚度(r=0.528；r=0.528；r=0.370)的相关性与MS与整体厚度(r=0.505；r=0.498)和部门厚度(r=0.559；r=0.440；r=0.440；r=0.535；r=0.443)的相关性无显著差异。GCCT和RNFLT在分贝尺度上呈曲线关系。MS与GCCT和RNFLT的对数回归(使用分贝和1/L等级)在描述关联模式方面优于线性回归。结论SD-OCT测定的GCCT与MS的相关性类似于MS与pRNFLT之间的相关性。(投资眼科VS科学。2010年；51：6401-6407)doi：10.1167/iovs.09-5035
PURPOSE. To evaluate the strength and pattern of the relationship between visual field (VF) mean sensitivity (MS), assessed by standard automated perimetry (SAP), and macular ganglion cell complex thickness (GCCT), measured with spectral-domain optical coherence tomography (SD-OCT).METHODS. Ninety-seven glaucoma patients were enrolled. GCCT, determined by ganglion cell complex (GCC) scanning, and two peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements, using the NHM4 (RNFL1) and RNFL 3.45 (RNFL2) modes, were recorded. MS was recorded on the decibel (dB) and 1/L scales. The relationship between function (MS) and structure (GCC, pRNFLT) was sought.RESULTS. The association of MS (in decibels) with GCC global (r = 0.445) and sectoral (superior, r = 0.528; inferior, r = 0.370) thicknesses was not significantly different from that of MS to global (RNFL1, r = 0.505; RNFL2, r = 0.498) and sectoral (RNFL 1 superior, r = 0.559; inferior, r = 0.440; RNFL 2 superior, r = 0.535; inferior, r = 0.443) pRNFLT, on linear regression analysis. The relationship pattern was curvilinear on the dB scale against GCCT and RNFLT. Logarithmic regression of MS (using both the dB and 1/L scales) against GCCT and RNFLT was better than linear regression in describing the pattern of association.CONCLUSIONS. GCCT, determined by SD-OCT, showed correlation to MS of a strength similar to that demonstrated between MS and pRNFLT. (Invest Ophthalmol Vis Sci. 2010;51:6401-6407) DOI:10.1167/iovs.09-5035