Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging
Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging
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DOI：
10.1021/acs.orglett.1c02862
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发表时间：
2021-09-22
期刊：
影响因子：
5.2
通讯作者：
Scott, Colleen N.
中科院分区：
文献类型：
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作者：
Rathnamalala, Chathuranga S. L.;Pino, Nicholas W.;Scott, Colleen N.
目前，以杂蒽为基础的近红外（NIR）光声（PA）染料的吸光度很少。由于获得这些染料需要漫长而繁琐的合成步骤，我们设计了一种含噻吩哌啶供体和杂蒽受体的近红外染料（XanthCR-880），只需3-4个合成步骤即可获得。该染料在880nm处具有强的PA信号，具有良好的生物相容性和光稳定性，与aza-BODIPY参考染料产生多路成像，并且在4cm深度下可检测到。
Few xanthene-based near-infrared (NIR) photo-acoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.