Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria.
Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria.
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DOI：
10.1016/j.kint.2021.03.038
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发表时间：
2021-07
影响因子：
19.6
通讯作者：
Wester CW
中科院分区：
文献类型：
--
作者：
Wudil UJ;Aliyu MH;Prigmore HL;Ingles DJ;Ahonkhai AA;Musa BM;Muhammad H;Sani MU;Nalado AM;Abdu A;Abdussalam K;Shepherd BE;Dankishiya FS;Burgner AM;Ikizler TA;Wyatt CM;Kopp JB;Kimmel PL;Winkler CA;Wester CW
HIV-positive adults are at risk for various kidney diseases, and apolipoprotein 1 (APOL1) high-risk genotypes increase this risk. This study aimed to determine the prevalence and ethnic distribution of APOL1 risk genotypes among a cohort of HIV-positive Nigerian adults and explore the relationship between APOL1 risk variant status with albuminuria and estimated glomerular filtration rate (eGFR). We conducted a cross-sectional study among 2 458 persons living with HIV who attended an HIV clinic in northern Nigeria and had received antiretroviral therapy for a minimum of six months. We collected two urine samples four-eight weeks apart to measure albumin excretion, and blood samples to measure eGFR and determine APOL1 genotype. The frequency of APOL1 high-risk genotype was 6.2%, which varied by ethnic group: Hausa/Fulani (2.1%), Igbo (49.1%), and Yoruba (14.5%). The prevalence of microalbuminuria (urine/albumin creatinine ratio 30 – 300 mg/g) was 37%, and prevalence of macroalbuminuria (urine/albumin creatinine ratio over 300 mg/g) was 3%. The odds of microalbuminuria and macroalbuminuria were higher for participants with the APOL1 high-risk genotype compared to those carrying the low-risk genotype ((adjusted odds ratio 1.97, 95% confidence interval 1.37-2.82) and (3.96, 1.95-8.02) respectively)). APOL1 high-risk genotype participants were at higher risk of having both an eGFR under 60 ml/min/1.73m2 and urine/albumin creatinine ratio over 300 mg/g (5.56, 1.57-19.69). Thus, we found a high proportion of HIV-positive, antiretroviral therapy-experienced, and largely virologically suppressed adults had microalbuminuria. Hence, although the high-risk APOL1 genotype was less prevalent than expected, it was strongly associated with some level of albuminuria.
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DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
30.8
作者：
Kopp, Jeffrey B.;Smith, Michael W.;Nelson, George W.;Johnson, Randall C.;Freedman, Barry I.;Bowden, Donald W.;Oleksyk, Taras;McKenzie, Louise M.;Kajiyama, Hiroshi;Ahuja, Tejinder S.;Berns, Jeffrey S.;Briggs, William;Cho, Monique E.;Dart, Richard A.;Kimmel, Paul L.;Korbet, Stephen M.;Michel, Donna M.;Mokrzycki, Michele H.;Schelling, Jeffrey R.;Simon, Eric;Trachtman, Howard;Vlahov, David;Winkler, Cheryl A.
通讯作者：
Winkler, Cheryl A.
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
DOI：
10.1086/600890
发表时间：
2009-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Gupta SK;Komarow L;Gulick RM;Pollard RB;Robbins GK;Franceschini N;Szczech LA;Koletar SL;Kalayjian RC
通讯作者：
Kalayjian RC
影响因子：
3.7
作者：
Ekrikpo UE;Kengne AP;Bello AK;Effa EE;Noubiap JJ;Salako BL;Rayner BL;Remuzzi G;Okpechi IG
通讯作者：
Okpechi IG