A new method for evaluating the bitterness of medicines by semi-continuous measurement of adsorption using a taste sensor
A new method for evaluating the bitterness of medicines by semi-continuous measurement of adsorption using a taste sensor
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DOI：
10.1248/cpb.49.1336
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发表时间：
2001-10-01
影响因子：
1.7
通讯作者：
Matsuyama, K
中科院分区：
文献类型：
--
作者：
Uchida, T;Kobayashi, Y;Matsuyama, K
我们描述了一种通过使用多通道味觉传感器或“电舌”半连续测量吸附来评估药物苦味的新方法。通过味觉传感器和 11 名志愿者的人体味觉测试评估了 10 种基本药物的苦味。味觉传感器的传感器部分由八个由脂质/聚合物膜制成的电极组成。从味觉传感器数据中获得三个变量：传感器输出（S）、吸附引起的膜电位变化（对应于余味（C））以及C/S比率。这些变量用于预测多元回归分析中的估计苦味分数。采用半连续测量C（每30秒至150秒）作为附加解释变量，并将C的衰减率定义为C。这些数据也进行了多元回归分析。使用通道 2 的 C 和通道 4 的 CIS 来估计味觉传感器预测的苦味分数的相关系数 (r)，以及通过人类味觉获得的分数，为 0.824。该值大于使用 C/S 为通道 2 和 4 获得的值 (0.734)。本研究中描述的方法似乎为苦味的评估提供了良好的可预测性。
We describe a new method for the evaluation of the bitterness of medicines by semi-continuous measurement of adsorption using a multichannel taste sensor or 'electric tongue'. The bitterness of 10 basic medicines was evaluated by both the taste sensor and in human gustatory sensation tests with 11 volunteers. The sensor part of the taste sensor consists of eight electrodes made of lipid/polymer membranes. Three variables were obtained from the taste sensor data: sensor output (S), the change of membrane potential caused by adsorption, corresponding to aftertaste (C), and the ratio C/S. These variables were used to predict an estimated bitterness score in multiple regression analysis. Semi-continuous measurement of C (every 30 s up to 150 s) was adopted as an additional explanatory variable, and the attenuation rate of C was defined as C. These data were also subjected to multiple regression analysis. The correlation coefficient (r) estimated for the bitterness score predicted by the taste sensor, using C for channel 2 and CIS for channel 4, and the score obtained by human gustatory sensation, was 0.824. This value was greater than that obtained using C/S for both channels 2 and 4 (0.734). The method described in the present study seems to offer good predictability for the evaluation of bitterness.