Natural Products as a Foundation for Drug Discovery.
Natural Products as a Foundation for Drug Discovery.
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DOI：
10.1002/0471141755.ph0911s46
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发表时间：
2009-09-01
影响因子：
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通讯作者：
Beutler, John A
中科院分区：
文献类型：
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作者：
Beutler, John A
天然产物有助于开发用于各种适应症的许多药物。虽然大多数美国制药公司已经减少或消除了其内部的天然产品组，但新的范式和新的企业已经发展到天然产品在制药行业中的作用。天然产品受欢迎程度下降的许多原因正在通过开发新的筛选和生产技术来解决。本综述旨在告知药理学家当前的策略和技术，使天然产品成为药物发现计划中可行的战略选择。
Natural products have contributed to the development of many drugs for diverse indications. While most U.S. pharmaceutical companies have reduced or eliminated their in-house natural product groups, new paradigms and new enterprises have evolved to carry on a role for natural products in the pharmaceutical industry. Many of the reasons for the decline in popularity of natural products are being addressed by the development of new techniques for screening and production. This overview aims to inform pharmacologists of current strategies and techniques that make natural products a viable strategic choice for inclusion in drug discovery programs.